Product Life Cycle Extension

Finding a New Drug to Keep Market Share

You have a key asset approaching loss of market exclusivity that needs an improved compound for a follow-on product:
    1. PharmetRx® uses chemo-modeling to define features of existing compound as the "exemplar" compound.
    2. Exemplar compound hits multiple targets in non-overlapping pathways.
    3. Primary drug target and relevant disease pathway defined in using drug targets v.s disease processes analysis.
    4. Exemplar compound scaffold selected as starting point for new derivatives and analogues.
    5. Computational modeling identifies best set of compounds for testing.
    6. Selection of 7 compounds synthesized and tested in cellular model to select best activity.
    7. Two compounds selected as lead candidates.
    8. Client receives compounds for further testing.

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